Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2
Description
The 2',5'- oligoadenylate synthetase (OAS) - ribonuclease L (RNAseL) - phosphodiesterase 12 (PDE12) pathway is an essential interferon-induced effector mechanism against RNA virus infection. Inhibition of PDE12 leads to selective amplification of
