Single-cell RNA-sequencing (scRNA-Seq) of bronchoalveolar lavage (BAL) cells has provided insights into COVID-19. However, reports have been limited by small patient cohorts. We performed a meta-analysis of BAL scRNA-Seq data from healthy controls (n
The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2's nsp14 protein is essential for viral replication and is a target for the development of new antivirals. Nsp14 uses S-adenosyl methionine (SAM) as the methyl donor to cap the 5' end of the
Malaria has, to a great extent, become normalized and accepted as inevitable. To resume global progress on malaria elimination, national malaria programs in many malaria-endemic countries urgently need to add new tactics. The global COVID-19
People's lifestyles play a major role in disease risk. Some employment sectors and transport modes involve fixed exposures regardless of community size, while in other settings exposure tracks with population density. MERS-CoV, a coronavirus
CONCLUSION: All patient groups displayed a shorter disease duration if the onset of neurological symptoms occurred shortly after the COVID-19 diagnosis. In particular, both the OMAS patients with symptom onset concurrent with COVID-19 showed only
CONCLUSION: The presence of coronary artery calcified plaque and cardiomegaly were high risks for severe prognosis and mortality in COVID-19 patients and may help to predict the survival of patients.
Although a novel oral antiviral agent can improve short-term COVID-19 outcomes, its effects on the long-term outcomes, namely the risk of major adverse cardiovascular events (MACEs), remains unknown. This retrospective cohort study used the TriNetX