A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication
Description
Covalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-2 have great potential as antivirals, but their non-specific reactivity with thiols has limited their development. In this report, we performed an 8000 molecule electrophile screen
